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Adjusted calcium is a calculation used to account for the influence of albumin, a protein in the blood that binds to calcium. Total calcium levels measured in routine blood tests include both ionized calcium (the active form that affects nerve and muscle function) and calcium bound to proteins like albumin. Changes in albumin levels can alter the amount of calcium bound to it, leading to variations in total calcium readings. Adjusted calcium corrects for these variations by estimating what the total calcium level would be if the albumin level were within the normal range.
Adjusted calcium levels in the body can be influenced by several factors. They are calculated based on total calcium and albumin levels in the blood, so changes in albumin levels can affect adjusted calcium readings. Acid-base imbalances, kidney function, and disorders affecting parathyroid hormone (PTH) secretion can also impact calcium balance and adjusted calcium levels. Additionally, vitamin D levels, medications like diuretics and corticosteroids, and various health conditions such as bone disorders and gastrointestinal diseases can all contribute to fluctuations in adjusted calcium levels. Monitoring adjusted calcium levels helps healthcare providers assess calcium metabolism, diagnose conditions like hypercalcemia or hypocalcemia, and manage overall health effectively.
