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Anti-CCP is a so-called autoantibody, i.e. a protein in the body that incorrectly attacks the body's own tissues and causes disease. The diseases that arise as a result of the formation of autoantibodies are usually called autoimmune diseases. Anti-CCP is an autoantibody that can occur in suspected rheumatoid arthritis ( joint rheumatism ), our most common rheumatic joint disease. Analysis of anti-CCP has similar sensitivity to analysis of rheumatoid factor (see this heading) for diagnosing rheumatoid arthritis, but anti-CCP is, however, a more specific test than rheumatoid factor is. This means that while the antibody rheumatoid factor can occur in several different rheumatic and inflammatory diseases , anti-CCP is usually only seen in the disease rheumatoid arthritis.
In the case of clinical symptoms that raise suspicion of the disease rheumatoid arthritis, anti-CCP can be analyzed to strengthen the diagnosis. Anti-CCP can also appear in the blood several years before the disease breaks out and anti-CCP is also a good measure to predict the aggressiveness of the disease.
Some joint-healthy people may also have anti-CCP in their blood, which is why the value should always be assessed together with clinical symptoms. However, the presence of anti-CCP in joint healthy people may increase the risk of developing rheumatoid arthritis in the future.
